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KMID : 1149120230200010001
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Journal of the Korean Society for Psoriasis
2023 Volume.20 No. 1 p.1 ~ p.5
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Immunologic Pathomechanism of Psoriasis and Atopic dermatitis
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Han Tae-Young
Lee Jung-Min
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Abstract
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Atopic dermatitis (AD) and psoriasis are inflammatory skin disorders that impose considerable burdens upon patient’s quality of life, health outcome, and work productivity. Atopic dermatitis involves erythematous patches that are not well demarcated and are often excoriated and associated with severe pruritus. Psoriasis presents with well-demarcated plaques covered with silvery white scales with variable levels of pruritus. Despite important clinical distinctions, the two disorders are similar in that epidermal keratinocytes respond to T-cell derived cytokines by altering growth and differentiation responses, accounting for major parts of the overall disease phenotype. Psoriasis is a disease largely driven by Th17 T-cells and associated IL-17 activation, while AD has a strong Th2 component associated with IL-4, IL-13 over-production, and both disorders have activation of Th22 T-cells and Th1 pathways with increased IL-22 and IFN-γ production. AD is a disease frequently associated with increased IgE production and overt allergies or asthma, most likely due to increased Th2 activation, which is largely lacking in psoriasis. In, this article, I will review and compare the immunopathogenesis of AD and psoriasis.
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KEYWORD
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Atopic dermatitis, Immunologic, Pathomechanism, Psoriasis
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